It has long been accepted that a gene's protein-coding information is contained in only one of its two DNA strands. But in 22 February Nature, Victor Corces and co-workers at the Department of Biology ...

Transcription and translation are processes a cell uses to make all proteins the body needs to function from information stored in the sequence of bases in DNA. The four bases (C, A, T/U, and G in the ...

Every time a cell divides, it must copy its entire genome so that each daughter cell inherits a complete set of DNA. During that process, enzymes known as polymerases race along the DNA to copy its ...

A graphic of a purple and magenta Cas9 protein, which is a somewhat round, but uneven, ball, bound to a yellow and orange ...

Most biochemistry labs that study DNA isolate it within a water-based solution that allows scientists to manipulate DNA without interacting with other molecules. They also tend to use heat to separate ...

(L to R) Co-first author Jackson Mobley, PhD, corresponding author Daniel Savic, PhD, and co-first author Kashi Raj Bhattarai, PhD, all of the St. Jude Department of Pharmacy and Pharmaceutical ...

Following a double-strand DNA break, an enzyme called PARP1 helps hold the two strands together —like superglue— and creates a safe zone for other proteins to come repair the damage. We don’t exactly ...

Ribbon structure of the BRCA2 protein. Mutations in the BRCA2 gene are linked to increased risk of breast cancer. New work from UC Davis shows how individual BRCA2 proteins work to repair damaged DNA, ...

Scientists have discovered that a protein once thought to simply help load a factor necessary for the copying of DNA, actually plays a key role in ensuring fast and reliable replication—an insight ...