New open-source Python-based software boosts space-weather modeling

University of Birmingham experts have created open-source computer software that helps scientists understand how fast-moving ...
eLife

Molidustat Targets a Synthetic Lethal Vulnerability in APC-Mutant Colorectal Cancer through GSTP1 and PHD2 Co-Inhibition

This important paper substantially advances our understanding of how Molidustat may work, beyond its canonical role, by identifying its therapeutic targets in cancer. This study presents a compelling ...
Hackaday

Python Comes To The Arduino Uno Q

MicroPython is a well-known and easy-to-use way to program microcontrollers in Python. If you’re using an Arduino Uno Q, ...
eLife

Gβγ engages PLCβ3 at multiple sites to reorient and facilitate its activation

EM, biochemical, and cell-based assays to examine how Gβγ interacts with and potentiates PLCβ3. The authors present evidence for multiple Gβγ interaction surfaces and argue that Gβγ primarily enhances ...
AHA/ASA Journals

Targeting Interleukin-8–Mediated Cellular Crosstalk Reverses Hypertrophic Cardiomyopathy and Cardiac Fibrosis in Noonan Syndrome

BACKGROUND: Genetic variants in components or regulators of the RAS-MAPK signaling pathway are causative for severe and early-onset hypertrophic cardiomyopathy (HCM) in patients with Noonan syndrome ...