Technology Networks

Long-Read RNA Sequencing Platform Helps Diagnose Rare Diseases

Researchers developed STRIPE, a targeted long-read RNA sequencing tool that identifies disease-causing variants missed by standard tests, improving diagnosis and enabling precision therapies for rare ...
Nature

Genome-wide analysis of DNA copy number variation in breast cancer using DNA microarrays

Gene amplifications and deletions frequently have pathogenetic roles in cancer. 30,000 radiation-hybrid mapped cDNAs provide a genomic resource to map these lesions with high resolution. We developed ...
Nature

Microarray analysis of the DNA-dependent protein kinase catalytic subunit knock-out mouse: global effects on gene regulation and the cellular response to ionizing radiation

We have generated transgenic mice carrying targeted deletions of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) gene. These animals offer the unique opportunity to gain insights into ...
Harvard Medical School

Massive Ancient-DNA Study Reveals Natural Selection Has Accelerated in Recent Human Evolution

The work demonstrates the power of ancient DNA to illuminate human biology and medicine in addition to history. A massive ...

Researchers create Olympic gels, a long-theorized class of DNA-based soft materials

An interdisciplinary research team led by Dr. Elisha Krieg at the Leibniz Institute of Polymer Research Dresden (IPF) has ...
AHA/ASA Journals

Targeting Interleukin-8–Mediated Cellular Crosstalk Reverses Hypertrophic Cardiomyopathy and Cardiac Fibrosis in Noonan Syndrome

BACKGROUND: Genetic variants in components or regulators of the RAS-MAPK signaling pathway are causative for severe and early-onset hypertrophic cardiomyopathy (HCM) in patients with Noonan syndrome ...