Duke Pratt School of Engineering

Beyond the Cut: A New Era for CRISPR Medicine

Charles Gersbach and his colleagues are pursuing promising CRISPR technologies focused on controlling gene activity rather ...
Drug Target Review

Variant or viable target? How resolving complex genomic regions is reshaping rare disease therapeutics

Dr Aaron Wenger reveals how improvements in long-read sequencing technology is enabling the elucidation of complex disease ...

Neanderthals may have shared key DNA for complex language, reshaping when human speech began

In a first-of-its-kind finding, researchers at University of Iowa Health Care discovered that specific genetic sequences have ...

E. coli editing technique expands into a universal toolkit for rewriting bacterial DNA

The ability to precisely edit the genomes of bacteria has long been a goal of microbiologists. Such technology would enable ...
eLife

Neurotrophin-3 produced by motor neurons non-cell autonomously regulate the development of pre-motor interneurons in the developing spinal cord

This is a useful study that seeks to elucidate the molecular mechanisms underlying spinal motor circuit assembly. The authors demonstrate that loss of Onecut transcription factors in spinal motor ...