Self‑replicating circular RNA persists in extreme environments: Insights from hot spring microbiomes

Although the genetic material of most living organisms is DNA, various self-replicating agents rely instead on RNA, including ...

Hidden mosquito viruses emerge as RNA immune signals map global infections

Aedes aegypti, commonly known as the yellow fever mosquito, is a highly adapted, invasive mosquito species recognized as a ...
eLife

The long-range gene regulatory landscape of cerebellar granule neuron progenitors

Neuronal specification, expansion and differentiation are tightly regulated by the concerted actions of transcription and chromatin modifying factors that are recruited to regulatory elements in the ...
Nature

Cancer therapy using a self-replicating RNA vaccine

The alternative text for this image may have been generated using AI. Figure 2: Anti-tumor effects mediated by self-replicating RNA vaccines. The alternative text for this image may have been ...
eLife

Molidustat Targets a Synthetic Lethal Vulnerability in APC-Mutant Colorectal Cancer through GSTP1 and PHD2 Co-Inhibition

This important paper substantially advances our understanding of how Molidustat may work, beyond its canonical role, by identifying its therapeutic targets in cancer. This study presents a compelling ...