Sequence alignment algorithms form the foundation of comparative genomics, structural biology and evolutionary studies by identifying regions of similarity among nucleotide or protein sequences.

Open-access databases such as the European Nucleotide Archive (ENA) contain more than 2.4 million bacterial genomes, and this number continues to grow rapidly. Until now, searching these vast ...

Rapidly growing protein databases demand faster sensitive search tools. Here the graphics processing unit (GPU)-accelerated MMseqs2 delivers 6× faster single-protein searches than CPU methods on 2 × ...

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