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med's go on Instagram: "The most common mechanism of bacterial resistance to macrolides is methylation of the 23S rRNA of the bacterial 50S ribosomal subunit. This methylation prevents the macrolide from binding to its target site, thereby conferring cross-resistance to structurally related drugs such as clindamycin and streptogramins (MLS_B resistance). This mechanism is typically mediated by erm (erythromycin ribosome methylase) genes. Unlike β-lactamase production or porin changes, this resis
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